WORK

JONATHAN SIEGRIST

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WORK

OBJECTIVE

Drive transformational healthcare change as a strategic, innovative, and technical leader in the area of medical devices, in vitro diagnostics, and biosensors.

I am driven by top teams working on revolutionary products that will drastically improve healthcare. My goal is to strategically drive & technically manage innovative initiatives that change the game for patients and providers alike. I work for patients.

 


TECHNICAL PROFILE

  • Strong interdisciplinary engineering and biomedical background
  • Extensive experience with systems, devices, and technology integration
  • Design, prototyping, and large scale manufacture of medical devices 
  • Hardware and software development for instrumentation support
  • Assay development including surface chemistries and signal transduction


PERSONAL PROFILE

  • Proven leadership in cross-functional R&D and Ops environments
  • Have led global, multi-disciplinary teams of over 150+ associates
  • Proven program/project management with 10+ IVD product launches
  • Natural leader with excellent communication and management skills
  • •  Persistent and creative problem solver
  • Excels in challenging environments



EDUCATION

  • Ph.D., Biomedical Engineering
    • University of California, Irvine
  • M.S., Biomedical Engineering
    • University of California, Irvine
  • B.S., Electrical Engineering w/Biomedical Engineering Option
    • University of California, Los Angeles



EXPERIENCE HIGHLIGHTS


CHIEF TECHNOLOGY OFFICER, CEPHEID: CTO leading and growing a group of 150+ global associates comprised of Cepheid’s dedicated early-stage Technology & Innovation Team as well as a dedicated Product Development unit focused on development and launch f next-generation multiplex molecular diagnostics systems, software, consumables, and assays.


Key Outputs: supported key aspects of Cepheid’s growth and products during COVID, led the successful M&A close and integration of a pre-revenue company with technology that enables Cepheid’s next generation systems, and drove and supported key open/external innovation initiatives for alternate molecular diagnostic platforms and technologies, at both the Cepheid and Danaher levels


    

VICE PRESIDENT TECHNOLOGY & INNOVATION, CEPHEID: Grew and led Cepheid’s global innovation team of scientists, engineers, and tech scouts to drive organic and open-innovation projects focused on assay, chemistry, systems, and consumables to lay the foundation of Cepheid’s next-generation capabilities for the GeneXpert system and assays


Key Outputs: established a “light and fast” innovation idea/project framework to prioritize and drive projects, initiated multiple external partnership projects (incl. driving Danaher-backed start-up investments) to advance detection capabilities of the GeneXpert, drove innovation of host-response based assays, re-ignited Cepheid’s instrument/system development efforts with multiple next-gen systems, and contributed to multiple diligence, M&A, and strategic planning efforts for Cepheid and Danaher



SR. DIRECTOR ENGINEERING, CEPHEID: Special assignment reporting to Cepheid’s CEO/President leading large and cross-functional development teams focused on new iterations of GeneXpert systems


Key Outputs: moved the GeneXpert Omni platform, including assay hardware, assay, software, and manufacturing aspects, through the Technical Feasibility phase including the first real-world field studies in South Africa, led the engineering grant writing initiatives that resulted in a multi-tens of millions of dollars contract from the US government to help accelerate GeneXpert system and consumable technologies, and initiated and launched (CE-IVD) the new GeneXpert Edge system for TB & HIV diagnostics



DIRECTOR ENGINEERING PROGRAMS, CEPHEID: Director of the Engineering Consumables R&D Group & technical program director of the Cepheid-USPS-Northrop Grumman Biohazard Detection System (BDS) partnership


Key Outputs: established the Engineering Consumables R&D group, led the R&D group to design a new injection-molded GeneXpert cartridge component for high-multiplexing & demonstrated PCR proof-of-concept, and addressed BDS program business continuity concerns to maintain the program’s multi-million dollar yearly revenue stream



PROGRAM MANAGER, CEPHEID: Product development program/project manager across all areas at Cepheid, including hardware/instrument systems, software, and assays/cartridges


Key Outputs: 10+ IVD product launches including worldwide launch of the GX Infinity-80 instrument the Xpert CT/NG assay



CO-FOUNDER & LEAD ENGINEER, IGLYKO, INC. FOR GLUCOSE SENSING: Worked in the business, financial, and technical arms of the company for the development of a fluorescence-based continuous glucose-sensing intravenous catheter


Key Outputs: developed hydrogel chemistries, fabricated fiber-optic systems, and established proof-of-concept in whole blood



SKILLS OVERVIEW


STRATEGY: strategic planning, landscape assessments, ROIC models, voice-of-customer, and numerous framework tools


INNOVATION: innovation process incl. Technology Readiness Levels, portfolio management, and early-stage investments


LEADERSHIP: global and multi-disciplinary team building and leadership, situational leadership, $50M+ budget responsibility


MANUFACTURING: multi-cavity injection molding incl. overmolding, lyophilization, high-throughput assembly and automation, IOPQ, process validation, and QC/failure investigation


FABRICATION: CNC prototyping, injection-molding, bonding, surface treatments, MEMS/photolithography/cleanrooms


BIO/CHEMICAL: DNA/RNA assays (amplification reactions), immunoassays, surface immobilization, gel/matrix chemistries


SYSTEMS: electrical, optical (fiber-optics, LEDs, PMTs), thermal (thermoelectrics, thermal modeling), magnetics


SOFTWARE: CAD (SolidWorks, Pro/E, AutoCAD), CAM (Pro/E), LabVIEW, Microsoft Project, Minitab, Windows, Mac


PUBLICATIONS: 30+ conferences and papers including numerous 1st authorships


IVD STANDARDS: ISO 13485 (CE-IVD, IVDD and IVDR), ISO 14971, QSR 21 CFR 820, Risk Mgmt/FMEA, Tech File, 510(k)



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PUBLICATIONS


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AT A GLANCE


DEGREE          



FIELDS



EXPERIENCE

Ph.D., Biomedical Engineering and
B.S., Electrical Engineering


Medical devices, in vitro diagnostics, molecular, and biosensors


Technical and strategy leader with track record of driving cross-functional teams, large and small, from early stage ideation though development & validation to regulatory approval and launch

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